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Side effects or adverse reactions of using minoxidil can be seen in most minoxidil reviews. Minoxidil is a drug and it is not uncommon for some individuals to experience side effects. Minoxidil has been proven safe to use by leading organizations in many countries. However, there are no guarantees on how an individual reacts to a certain drug. The most common side effect is itchiness. Some men will experience itchiness during their first few applications. Another side effect is eye irritation. Actually, this can be caused by allowing the medicine to come into contact with the eyes. If possible, avoid using the hands to apply the medicine. Another common side effect is scaling and this usually looks like dandruff flakes. The scaling occurs when the medicine dries on your scalp and leaves a residue. It would be better to use a shampoo after applying the product to make sure that there would be no residue left.